Title : Src-family protein tyrosine kinase phosphorylates WNK4 and modulates its inhibitory effect on KCNJ1 (ROMK).

Pub. Date : 2015 Apr 7

PMID : 25805816






2 Functional Relationships(s)
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1 We conclude that WNK4 is a substrate of SFKs and that the association of c-Src and PTP-1D with WNK4 at Tyr(1092) and Tyr(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK. Tyrosine potassium inwardly rectifying channel subfamily J member 1 Homo sapiens
2 We conclude that WNK4 is a substrate of SFKs and that the association of c-Src and PTP-1D with WNK4 at Tyr(1092) and Tyr(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK. Tyrosine potassium inwardly rectifying channel subfamily J member 1 Homo sapiens