Title : The loss of Tm7sf gene accelerates skin papilloma formation in mice.

Pub. Date : 2015 Mar 25

PMID : 25804527






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TPA increased skin cholesterol levels by inducing de novo synthesis and up-take only in Tm7sf2(+/+) mouse, confirming that the gene maintains cholesterol homeostasis under stress conditions. Tetradecanoylphorbol Acetate transmembrane 7 superfamily member 2 Mus musculus
2 Cholesterol sulfate, one of the major players in skin permeability, was doubled by TPA treatment in the skin of wild-type animals but this response was lost in Tm7sf2(-/-) mice. Tetradecanoylphorbol Acetate transmembrane 7 superfamily member 2 Mus musculus