Pub. Date : 2015
PMID : 25803856
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MD-2 determinants of nickel and cobalt-mediated activation of human TLR4. | Cobalt | toll like receptor 4 | Homo sapiens |
| 2 | Human TLR4/MD-2 was also activated by cobalt ions, while copper and cadmium were toxic in the tested concentration range. | Cobalt | toll like receptor 4 | Homo sapiens |
| 3 | Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. | Cobalt | toll like receptor 4 | Homo sapiens |
| 4 | Activation of TLR4 by cobalt required MD-2 and was abolished by human TLR4 mutations of histidine residues at positions 456 and 458. | Cobalt | toll like receptor 4 | Homo sapiens |
| 5 | We demonstrated that activation of TLR4 by nickel and cobalt ions can trigger both the MyD88-dependent and the -independent pathway. | Cobalt | toll like receptor 4 | Homo sapiens |