Title : Cisplatin-mediated c-myc overexpression and cytochrome c (cyt c) release result in the up-regulation of the death receptors DR4 and DR5 and the activation of caspase 3 and caspase 9, likely responsible for the TRAIL-sensitizing effect of cisplatin.

Pub. Date : 2015 Apr

PMID : 25796504






1 Functional Relationships(s)
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1 We found that after treatment with TRAIL, the DNA-PKcs/Akt/GSK-3beta pathway, which is positively correlated with the levels of MDR1 and MRP1, was significantly inhibited and that this tendency can be abolished by Z-DEVD-FMK (a specific caspase 3 inhibitor). benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone caspase 3 Homo sapiens