Title : Spatio-temporal model of endogenous ROS and raft-dependent WNT/beta-catenin signaling driving cell fate commitment in human neural progenitor cells.

Pub. Date : 2015 Mar

PMID : 25793621






2 Functional Relationships(s)
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1 Accordingly after initiation of differentiation endogenous ROS activates DVL in a redox-dependent manner leading to a transient activation of down-stream beta-catenin signaling, followed by continuous auto/paracrine WNT signaling, which crucially depends on lipid rafts. Reactive Oxygen Species dishevelled segment polarity protein 1 pseudogene 1 Homo sapiens
2 Our simulation studies further illustrate the elaborate spatio-temporal regulation of DVL, which, depending on its concentration and localization, may either act as direct inducer of the transient ROS/beta-catenin signal or as amplifier during continuous auto-/parcrine WNT/beta-catenin signaling. Reactive Oxygen Species dishevelled segment polarity protein 1 pseudogene 1 Homo sapiens