Pub. Date : 2015 Jul 1
PMID : 25791922
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | As a result, curcumin reduced TXNIP expression and inhibited NLRP3 inflammasome activation by downregulation of NLRP3 and cleaved caspase-1 induction, and thus reduced IL-1beta secretion. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Immunohistochemistry showed that curcumin inhibited p-IRE1alpha, p-PERK and NLRP3 expression in hippocampus CA1 region. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult. | Curcumin | NLR family pyrin domain containing 3 | Homo sapiens |