Title : Phosphorothioate modification of chimeric 2ยด-O-methyl RNA/ethylene-bridged nucleic acid oligonucleotides increases dystrophin exon 45 skipping capability and reduces cytotoxicity.

Pub. Date : 2015 Feb 17

PMID : 25791417






2 Functional Relationships(s)
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1 Phosphorothioate modification of chimeric 2 -O-methyl RNA/ethylene-bridged nucleic acid oligonucleotides increases dystrophin exon 45 skipping capability and reduces cytotoxicity. ethylene dystrophin Homo sapiens
2 An antisense chimeric oligonucleotide consisting of 2 -O-methyl RNA and ethylene-bridged nucleic acid (ENA), targeting exon 45 of the dystrophin gene, AO85, has been shown to induce exon 45 skipping efficiently. ethylene dystrophin Homo sapiens