Pub. Date : 2015 Apr
PMID : 25780442
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin inhibits the proliferation of A431 cells by modulating the PI3K/Akt signaling pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Western blotting results showed that the protein expression levels of PI3K and p-Akt were inhibited by metformin in a time- and dose-dependent manner (P<0.05). | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, metformin significantly inhibited the proliferation of A431 cells in the current study, which may be strongly associated with the inhibition of the PI3K/Akt signaling pathway. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |