Title : Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.

Pub. Date : 2015 Mar 12

PMID : 25766326






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SPOP specifically recognizes multiple Ser/Thr (S/T)-rich degrons located in the AF2 domain of ERalpha, and triggers ERalpha degradation via the ubiquitin-proteasome pathway. Serine estrogen receptor 1 Homo sapiens