Title : Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.

Pub. Date : 2015 Feb

PMID : 25760532






3 Functional Relationships(s)
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1 Among the 41 compounds tested, trimethylamine, methimazole, itopride, and tozasertib (50 muM) suppressed benzydamine N-oxygenation at a substrate concentration of 50 muM by approximately 50% after co-incubation. Methimazole latexin Homo sapiens
2 Among the 41 compounds tested, trimethylamine, methimazole, itopride, and tozasertib (50 muM) suppressed benzydamine N-oxygenation at a substrate concentration of 50 muM by approximately 50% after co-incubation. Methimazole latexin Homo sapiens
3 Apparent competitive inhibition by methimazole (0-50 muM) of sulindac sulfide S-oxygenation was observed with FMO3 proteins. Methimazole latexin Homo sapiens