Pub. Date : 2015
PMID : 25759055
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure. | fexofenadine | solute carrier organic anion transporter family member 2B1 | Homo sapiens |
| 2 | Moreover, in in vitro studies, the uptake of both fexofenadine enantiomers into OATP2B1 cRNA-injected oocytes was significantly higher than that into water-injected oocytes, and this effect was greater for (R)-fexofenadine. | fexofenadine | solute carrier organic anion transporter family member 2B1 | Homo sapiens |
| 3 | Furthermore, OATP2B1 is a key determinant of the stereoselective pharmacokinetics of fexofenadine, and drug transporters may have chiral discrimination ability. | fexofenadine | solute carrier organic anion transporter family member 2B1 | Homo sapiens |