Title : LTP-triggered cholesterol redistribution activates Cdc42 and drives AMPA receptor synaptic delivery.

Pub. Date : 2015 Mar 16

PMID : 25753037






1 Functional Relationships(s)
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1 A reduction in cholesterol, in turn, leads to the activation of Cdc42 and the mobilization of GluA1-containing alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors (AMPARs) from Rab11-recycling endosomes into the synaptic membrane, leading to synaptic potentiation. Cholesterol RAB11A, member RAS oncogene family Homo sapiens