Title : Phenolic thio- and selenosemicarbazones as multi-target drugs.

Pub. Date : 2015 Apr 13

PMID : 25752525






2 Functional Relationships(s)
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1 Furthermore, one of the thiosemicarbazones was found to be a strong non-competitive inhibitor of alpha-glucosidase (Ki = 9.6 +- 1.6 muM), with an 8-fold increase in activity compared to acarbose (Ki = 77.9 +- 11.4 muM), marketed for the treatment of type-2 diabetes. Thiosemicarbazones latexin Homo sapiens
2 Furthermore, one of the thiosemicarbazones was found to be a strong non-competitive inhibitor of alpha-glucosidase (Ki = 9.6 +- 1.6 muM), with an 8-fold increase in activity compared to acarbose (Ki = 77.9 +- 11.4 muM), marketed for the treatment of type-2 diabetes. Thiosemicarbazones latexin Homo sapiens