Title : Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo.

Pub. Date : 2015 Feb

PMID : 25748238






2 Functional Relationships(s)
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1 Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1alpha in EGFR-mutated lung cancer in vitro and in vivo. Cisplatin MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 These results suggest that low dose erlotinib-cisplatin combination exhibits its anti-tumor activity by targeting angiogenesis through the modulation of the c-MYC/HIF-1alpha/VEGF pathway in NSCLC with EGFR exon 19 deletions. Cisplatin MYC proto-oncogene, bHLH transcription factor Homo sapiens