Title : ¹H- and ¹³C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer's disease.

Pub. Date : 2015 Apr

PMID : 25742870






1 Functional Relationships(s)
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1 Since GS is an ATP-dependent enzyme, mitochondrial dysfunction might contribute to reduced activity, which might also account for the increased metabolism of glutamate via the GABA shunt, a metabolic pathway to bypass intra-mitochondrial alpha-ketoglutarate-dehydrogenase, resulting in elevated GABA levels. Adenosine Triphosphate glutamate-ammonia ligase (glutamine synthetase) Mus musculus