Pub. Date : 2015 Mar 5
PMID : 25742604
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductase. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 2 | Here, we show that sterols stimulate binding of UBIAD1 to the cholesterol biosynthetic enzyme HMG CoA reductase, which is subject to sterol-accelerated, endoplasmic reticulum (ER)-associated degradation augmented by the nonsterol isoprenoid geranylgeraniol through an unknown mechanism. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 3 | Geranylgeraniol inhibits binding of UBIAD1 to reductase, allowing its degradation and promoting transport of UBIAD1 from the ER to the Golgi. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 4 | Geranylgeraniol inhibits binding of UBIAD1 to reductase, allowing its degradation and promoting transport of UBIAD1 from the ER to the Golgi. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 5 | CRISPR-CAS9-mediated knockout of UBIAD1 relieves the geranylgeraniol requirement for reductase degradation. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 6 | SCD-associated mutations in UBIAD1 block its displacement from reductase in the presence of geranylgeraniol, thereby preventing degradation of reductase. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |
| 7 | The current results identify UBIAD1 as the elusive target of geranylgeraniol in reductase degradation, the inhibition of which may contribute to accumulation of cholesterol in SCD. | geranylgeraniol | UbiA prenyltransferase domain containing 1 | Homo sapiens |