Title : Modulation of HMGB1 translocation and RAGE/NFκB cascade by quercetin treatment mitigates atopic dermatitis in NC/Nga transgenic mice.

Pub. Date : 2015 Jun

PMID : 25739980






2 Functional Relationships(s)
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1 Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p-NFkappaB, p-ERK1/2, COX2, TNFalpha, IL-1beta, IL-2Ralpha, IFNgamma and IL-4 and upregulated nuclear Nrf2. Quercetin nuclear factor, erythroid derived 2, like 2 Mus musculus
2 Our data demonstrated that the HMGB1/RAGE/NFkappaB signalling might play an important role in skin inflammation, and quercetin treatment could be a promising agent for AD by modulating the HMGB1/RAGE/NFkappaB signalling and induction of Nrf2 protein. Quercetin nuclear factor, erythroid derived 2, like 2 Mus musculus