Title : Pemetrexed induces apoptosis in malignant mesothelioma and lung cancer cells through activation of reactive oxygen species and inhibition of sirtuin 1.

Pub. Date : 2015 May

PMID : 25738249






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pemetrexed-induced apoptosis, which was prevented by pretreatment with N-acetyl-cysteine (NAC), was mediated by effects on the mitochondria, including mitochondrial membrane potential transition (MPT) and cytosolic release of cytochrome c, and also involved regulation of SIRT1 expression. Pemetrexed cytochrome c, somatic Homo sapiens