Title : Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer.

Pub. Date : 2015 Mar 17

PMID : 25737542






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We found that SCLCs were sensitized to ABT-263 via TORC1/2 inhibition, which led to reduced MCL-1 protein levels, thereby facilitating BIM-mediated apoptosis. bim CREB regulated transcription coactivator 1 Homo sapiens