Title : Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state.

Pub. Date : 2015 May

PMID : 25734998






1 Functional Relationships(s)
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1 We observed that intraplantar injection of the novel highly specific PAR2 agonist, 2-aminothiazol-4-yl-LIGRL-NH2 (2-at), evokes a long-lasting acute mechanical hypersensitivity (median effective dose ~12 pmoles), facial grimacing, and causes robust hyperalgesic priming as revealed by a subsequent mechanical hypersensitivity and facial grimacing to prostaglandin E2 (PGE2) injection. 2-Aminothiazoline hydrobromide pulmonary adenoma resistance 2 Mus musculus