Title : Combination of Matrine and Sorafenib Decreases the Aggressive Phenotypes of Hepatocellular Carcinoma Cells.

Pub. Date : 2014

PMID : 25721136






2 Functional Relationships(s)
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1 The suppressive effect of combining matrine and sorafenib was significantly reduced by miRNA-21 overexpression or PTEN inhibition. Sorafenib microRNA 21 Homo sapiens
2 CONCLUSION: Matrine in combination with sorafenib leads to increased cytotoxic effects against HCC cells, at least partially, via the suppression of miRNA-21 and the subsequent induction of PTEN. Sorafenib microRNA 21 Homo sapiens