Title : Albumin impairs renal tubular tight junctions via targeting the NLRP3 inflammasome.

Pub. Date : 2015 May 1

PMID : 25715986






1 Functional Relationships(s)
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1 Similarly, in albumin-overloaded wild-type mice, both ZO-1 and claudin-1 were downregulated at the protein and mRNA levels in parallel with the impaired formation of the tight junctions on transmission electron microscopy and the abnormal renal tubular morphology on periodic acid-Schiff staining, which contrasted with the stimulation of NLRP3 in the renal tubules. Periodic Acid claudin 1 Mus musculus