Title : A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis.

Pub. Date : 2015 Apr 17

PMID : 25713062






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TEM-1 is a prevalent plasmid-encoded beta-lactamase in Gram-negative bacteria that efficiently catalyzes the hydrolysis of penicillins and early cephalosporins but not oxyimino-cephalosporins. Cephalosporins CD248 molecule Homo sapiens