Title : Urodilatin and beta-ANF: binding properties and activation of particulate guanylate cyclase.

Pub. Date : 1989 Aug 30

PMID : 2570574






1 Functional Relationships(s)
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1 In adrenal cortex containing predominantly R1-receptors coupled to particulate guanylate cyclase, urodilatin binds with a higher affinity (KD: 30 pM) than ANF-(99-126) (KD: 52 pM) and stimulates to a similar extent to ANF-(99-126) (about two fold at 1 muM), whereas beta-ANF has a smaller affinity (KD: 120 pM) and stimulates particulate guanylate cyclase to a lower extent than ANF-(99-126). Ularitide latexin Homo sapiens