Title : Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.

Pub. Date : 2015 Jun

PMID : 25704054






2 Functional Relationships(s)
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1 The observed DNA demethylating activity of Clad and Clo may complement DAC activity; increase demethylation of the gene promoters for SFRP1, DKK3, and WIF1; and cause degradation of beta-catenin in cells exposed to Clad/Clo+Flu+Bu+DAC+Pano. Clofarabine WNT inhibitory factor 1 Homo sapiens
2 The observed DNA demethylating activity of Clad and Clo may complement DAC activity; increase demethylation of the gene promoters for SFRP1, DKK3, and WIF1; and cause degradation of beta-catenin in cells exposed to Clad/Clo+Flu+Bu+DAC+Pano. Clofarabine WNT inhibitory factor 1 Homo sapiens