Title : miR Profiling Identifies Cyclin-Dependent Kinase 6 Downregulation as a Potential Mechanism of Acquired Cisplatin Resistance in Non-Small-Cell Lung Carcinoma.

Pub. Date : 2015 Nov

PMID : 25703099






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The expression of cyclin-dependent kinase 6 (CDK6), a potential target of miR-145, was lower in resistant cells, and inhibition of CDK4/6 protected cells from cisplatin. Cisplatin cyclin dependent kinase 4 Homo sapiens
2 An inhibitor of CDK4/6 (PD0332991) protected parental NSCLC cells from cisplatin cytotoxicity. Cisplatin cyclin dependent kinase 4 Homo sapiens