Pub. Date : 2015 Jul
PMID : 25701378
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We further show that combined treatment with celecoxib and rapamycin results in an additive inhibitory effect on the growth of gastric cancer cells through suppression of rapamycin-induced Akt activation. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Knockdown of Cbl-b significantly attenuated celecoxib-mediated inhibition of Akt phosphorylation and impaired the additive anticancer effect of celecoxib and rapamycin. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Our results suggest that celecoxib-mediated upregulation of Cbl-b is responsible, at least in part, for the additive antitumor effect of celecoxib and rapamycin via inhibition of rapamycin-induced Akt activation. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Our results suggest that celecoxib-mediated upregulation of Cbl-b is responsible, at least in part, for the additive antitumor effect of celecoxib and rapamycin via inhibition of rapamycin-induced Akt activation. | Celecoxib | AKT serine/threonine kinase 1 | Homo sapiens |