Pub. Date : 2015 Jul
PMID : 25701378
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K/Akt pathway. | Sirolimus | Cbl proto-oncogene B | Homo sapiens |
| 2 | Knockdown of Cbl-b significantly attenuated celecoxib-mediated inhibition of Akt phosphorylation and impaired the additive anticancer effect of celecoxib and rapamycin. | Sirolimus | Cbl proto-oncogene B | Homo sapiens |
| 3 | Our results suggest that celecoxib-mediated upregulation of Cbl-b is responsible, at least in part, for the additive antitumor effect of celecoxib and rapamycin via inhibition of rapamycin-induced Akt activation. | Sirolimus | Cbl proto-oncogene B | Homo sapiens |
| 4 | Our results suggest that celecoxib-mediated upregulation of Cbl-b is responsible, at least in part, for the additive antitumor effect of celecoxib and rapamycin via inhibition of rapamycin-induced Akt activation. | Sirolimus | Cbl proto-oncogene B | Homo sapiens |