Title : Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system.

Pub. Date : 2015 Apr 15

PMID : 25701203






2 Functional Relationships(s)
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1 Here we evaluated the zebrafish as a potential pharmacological model for screening novel oxime antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE). Oximes acetylcholinesterase Danio rerio
2 However, differences between the Kox and k2 constants suggest that zebrafish AChE associates more tightly with oximes, but has a slower maximal reactivation rate than human AChE. Oximes acetylcholinesterase Danio rerio