Title : A PDI-catalyzed thiol-disulfide switch regulates the production of hydrogen peroxide by human Ero1.

Pub. Date : 2015 Jun

PMID : 25697776






2 Functional Relationships(s)
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1 Supported by O2 diffusion simulations, these data describe the first enzymatically controlled O2 access into a flavoprotein active site, provide molecular-level understanding of Ero1alpha regulation and H2O2 production/detoxification, and establish the deleterious consequences of constitutive Ero1 activity. Oxygen endoplasmic reticulum oxidoreductase 1 alpha Homo sapiens
2 Supported by O2 diffusion simulations, these data describe the first enzymatically controlled O2 access into a flavoprotein active site, provide molecular-level understanding of Ero1alpha regulation and H2O2 production/detoxification, and establish the deleterious consequences of constitutive Ero1 activity. Oxygen endoplasmic reticulum oxidoreductase 1 alpha Homo sapiens