Pub. Date : 2015 May 1
PMID : 25695518
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DBPA facilitates the bacteria"s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. | Glycosaminoglycans | Y-box binding protein 3 | Homo sapiens |
| 2 | DBPA facilitates the bacteria"s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide. | Glycosaminoglycans | Y-box binding protein 3 | Homo sapiens |
| 3 | Interestingly, DBPA sequence variation among different strains of Borrelia spirochetes is high, resulting in significant differences in their GAG affinities. | Glycosaminoglycans | Y-box binding protein 3 | Homo sapiens |
| 4 | In particular, the C-terminus of PBr DBPA, unlike C-termini from B31 and N40 DBPAs, is positioned away from the GAG-binding pocket and the linker between helices one and two of PBr DBPA is highly structured and retracted from the GAG-binding pocket. | Glycosaminoglycans | Y-box binding protein 3 | Homo sapiens |
| 5 | In particular, the C-terminus of PBr DBPA, unlike C-termini from B31 and N40 DBPAs, is positioned away from the GAG-binding pocket and the linker between helices one and two of PBr DBPA is highly structured and retracted from the GAG-binding pocket. | Glycosaminoglycans | Y-box binding protein 3 | Homo sapiens |
| 6 | The repositioning of the C-terminus allowed the formation of an extra GAG-binding epitope in PBr DBPA and the retracted linker gave GAG ligands more access to the GAG-binding epitopes than other DBPAs. | Glycosaminoglycans | Y-box binding protein 3 | Homo sapiens |