Pub. Date : 2015 Apr 10
PMID : 25694432
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The interaction of protein-tyrosine phosphatase alpha (PTPalpha) and RACK1 protein enables insulin-like growth factor 1 (IGF-1)-stimulated Abl-dependent and -independent tyrosine phosphorylation of PTPalpha. | Tyrosine | insulin like growth factor 1 | Homo sapiens |
| 2 | The interaction of protein-tyrosine phosphatase alpha (PTPalpha) and RACK1 protein enables insulin-like growth factor 1 (IGF-1)-stimulated Abl-dependent and -independent tyrosine phosphorylation of PTPalpha. | Tyrosine | insulin like growth factor 1 | Homo sapiens |
| 3 | The growth factor IGF-1 also stimulates PTPalpha-Tyr-789 phosphorylation to positively regulate cell movement. | Tyrosine | insulin like growth factor 1 | Homo sapiens |
| 4 | We found that PTPalpha binds to the scaffold protein RACK1 and that RACK1 coordinates the IGF-1 receptor, PTPalpha, and Abl in a complex to enable IGF-1-stimulated and Abl-dependent PTPalpha-Tyr-789 phosphorylation. | Tyrosine | insulin like growth factor 1 | Homo sapiens |