Pub. Date : 2015
PMID : 25689721
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ursolic acid attenuates diabetic mesangial cell injury through the up-regulation of autophagy via miRNA-21/PTEN/Akt/mTOR suppression. | ursolic acid | microRNA 21 | Homo sapiens |
| 2 | OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions. | ursolic acid | microRNA 21 | Homo sapiens |
| 3 | Ursolic acid down-regulated miRNA-21 expression and up-regulated PTEN protein and mRNA expression. | ursolic acid | microRNA 21 | Homo sapiens |
| 4 | CONCLUSIONS: Ursolic acid inhibits the glucose-induced up-regulation of mesangial cell miRNA-21 expression, up-regulates PTEN expression, inhibits the activation of PI3K/Akt/mTOR signaling pathway, and enhances autophagy to reduce the accumulation of the extracellular matrix and ameliorate cell hypertrophy and proliferation. | ursolic acid | microRNA 21 | Homo sapiens |