Title : Modulation of the IGF system and proliferation in human endometrial stromal cells by metformin: a dose-dependent effect.

Pub. Date : 2015 Aug

PMID : 25687657






1 Functional Relationships(s)
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1 Higher concentrations of metformin lead to a significant (p < 0.05) dose-dependent attenuation of the progesterone effect with regard to IGFBP-1, -3, -5, -6, as well as IGF I receptor, while it did not change the expression of IGFBP-2 and -4, IGF I and II and the IGF II receptor. Metformin insulin like growth factor 1 Homo sapiens