Title : 5'-(N-aminoacyl)-sulfonamido-5'-deoxyadenosine: attempts for a stable alternative for aminoacyl-sulfamoyl adenosines as aaRS inhibitors.

Pub. Date : 2015 Mar 26

PMID : 25686591






3 Functional Relationships(s)
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1 5"-(N-aminoacyl)-sulfonamido-5"-deoxyadenosine: attempts for a stable alternative for aminoacyl-sulfamoyl adenosines as aaRS inhibitors. aminoacyl-sulfamoyl adenosines alanyl-tRNA synthetase 1 Homo sapiens
2 Synthesis of aminoacyl-sulfamoyl adenosines (aaSAs) and their peptidyl conjugates as aminoacyl tRNA synthetase (aaRS) inhibitors remains problematic due to the low yield of the aminoacylation and the subsequent conjugation reaction causing concomitant formation of a cyclic adenosine derivative. aminoacyl-sulfamoyl adenosines alanyl-tRNA synthetase 1 Homo sapiens
3 Synthesis of aminoacyl-sulfamoyl adenosines (aaSAs) and their peptidyl conjugates as aminoacyl tRNA synthetase (aaRS) inhibitors remains problematic due to the low yield of the aminoacylation and the subsequent conjugation reaction causing concomitant formation of a cyclic adenosine derivative. aminoacyl-sulfamoyl adenosines alanyl-tRNA synthetase 1 Homo sapiens