Title : Lack of effect of metformin on mammary carcinogenesis in nondiabetic rat and mouse models.

Pub. Date : 2015 Mar

PMID : 25681088






1 Functional Relationships(s)
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1 In rats bearing small palpable mammary cancers, short-term metformin (150 mg/kg BW/d) treatment increased levels of phospho-AMPK and phospho-p53 (Ser20), but failed to reduce Ki67 labeling or expression of proliferation-related genes. Metformin Wistar clone pR53P1 p53 pseudogene Rattus norvegicus