Pub. Date : 1989 Jul 5
PMID : 2567735
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | gamma-Glutamate kinase, the enzyme that catalyzes the first step in the pathway from glutamate to proline, has been postulated to convert glutamate to a gamma-activated form (possibly gamma-glutamyl phosphate), which is reduced by a NADPH-linked reductase to yield glutamate gamma-semialdehyde (in equilibrium with delta 1-pyrroline-5-carboxylate). | Glutamic Acid | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 2 | gamma-Glutamate kinase, the enzyme that catalyzes the first step in the pathway from glutamate to proline, has been postulated to convert glutamate to a gamma-activated form (possibly gamma-glutamyl phosphate), which is reduced by a NADPH-linked reductase to yield glutamate gamma-semialdehyde (in equilibrium with delta 1-pyrroline-5-carboxylate). | Glutamic Acid | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |
| 3 | In the present work we found that the kinase, in the absence or presence of the reductase (and in the absence of NADPH), catalyzes stoichiometric formation of 5-oxo-L-proline and Pi from L-glutamate and ATP, but catalyzes hydroxamate formation at only about 10% of the rate of ATP-cleavage. | Glutamic Acid | 2,4-dienoyl-CoA reductase 1 | Homo sapiens |