Title : Genistein induces apoptosis by the inactivation of the IGF-1R/p-Akt signaling pathway in MCF-7 human breast cancer cells.

Pub. Date : 2015 Mar

PMID : 25675448






2 Functional Relationships(s)
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1 Furthermore, genistein induced the inactivation of IGF-1R and p-Akt and downregulated the Bcl-2/Bax protein ratio. Genistein BCL2 associated X, apoptosis regulator Homo sapiens
2 These results suggest that genistein inhibited cell proliferation by inactivating the IGF-1R-PI3 K/Akt pathway and decreasing the Bcl-2/Bax mRNA and protein expressions. Genistein BCL2 associated X, apoptosis regulator Homo sapiens