Pub. Date : 2015 Jun 15
PMID : 25662276
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mineralocorticoid receptor (MR) differs from the other steroid receptors in that it responds to two physiological ligands, aldosterone and cortisol. | Hydrocortisone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 2 | The mineralocorticoid receptor (MR) differs from the other steroid receptors in that it responds to two physiological ligands, aldosterone and cortisol. | Hydrocortisone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 3 | Molecular modelling has identified a region in the LBD of the MR and indeed other steroid receptors that critically defines ligand-specificity for aldosterone and cortisol, yet is not part of the ligand-binding pocket. | Hydrocortisone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |
| 4 | An interaction between the N-terminus and LBD observed in the MR is aldosterone-dependent but is unexpectedly antagonised by cortisol. | Hydrocortisone | nuclear receptor subfamily 3 group C member 2 | Homo sapiens |