Title : Perinatal nicotine exposure suppresses PPARĪ³ epigenetically in lung alveolar interstitial fibroblasts.

Pub. Date : 2015 Apr

PMID : 25661292






3 Functional Relationships(s)
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Protein Name
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1 Methylation inhibitor 5-aza-2"-deoxycytidine restored the nicotine-induced down-regulation of PPARgamma expression and the activation of its downstream myogenic marker fibronectin. Nicotine fibronectin 1 Rattus norvegicus
2 The knock down of DNMT1 and MeCP2 abolished nicotine-mediated increases in DNMT1 and MeCP2 protein levels, and PPARgamma promoter methylation, restoring nicotine-induced down regulation of PPARgamma and upregulation of the myogenic protein, fibronectin. Nicotine fibronectin 1 Rattus norvegicus
3 The knock down of DNMT1 and MeCP2 abolished nicotine-mediated increases in DNMT1 and MeCP2 protein levels, and PPARgamma promoter methylation, restoring nicotine-induced down regulation of PPARgamma and upregulation of the myogenic protein, fibronectin. Nicotine fibronectin 1 Rattus norvegicus