Title : Tolerance to nitroglycerin is caused by reduced guanylate cyclase activation.

Pub. Date : 1989 Jan

PMID : 2565981






3 Functional Relationships(s)
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Protein Name
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1 NG pre-incubation of GC (in contrast to coronary strips) almost completely abolished the direct and thiol-independent stimulatory effect of 3-morpholinosydnonimine (SIN-1) down to 4.5 +/- 0.2%, whereas pre-incubation with other nitrovasodilators reduced the stimulatory response to SIN-1 to only 59 to 98%. Nitroglycerin MAPK associated protein 1 Homo sapiens
2 NG pre-incubation of GC (in contrast to coronary strips) almost completely abolished the direct and thiol-independent stimulatory effect of 3-morpholinosydnonimine (SIN-1) down to 4.5 +/- 0.2%, whereas pre-incubation with other nitrovasodilators reduced the stimulatory response to SIN-1 to only 59 to 98%. Nitroglycerin MAPK associated protein 1 Homo sapiens
3 Increasing concentrations of NG during pre-incubation dose-dependently (IC50 = 0.13 mM) reduced the activating effect of SIN-1 during incubation. Nitroglycerin MAPK associated protein 1 Homo sapiens