Title : Intrathecal resiniferatoxin in a dog model: efficacy in bone cancer pain.

Pub. Date : 2015 Jun

PMID : 25659068






6 Functional Relationships(s)
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1 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris
2 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris
3 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris
4 Resiniferatoxin (RTX) is the most potent among all known endogenous and synthetic agonists for the transient receptor potential vanilloid 1 (TRPV1) receptor, which is a calcium-permeable nonselective cation channel, expressed on the peripheral and central terminals of small-diameter sensory neurons. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris
5 Prolonged calcium influx induced by RTX causes cytotoxicity and death of only those sensory neurons that express the TRPV1 ion channel leading to selective targeting and permanent deletion of the TRPV1-expressing C-fiber neuronal cell bodies in the dorsal root ganglia. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris
6 Prolonged calcium influx induced by RTX causes cytotoxicity and death of only those sensory neurons that express the TRPV1 ion channel leading to selective targeting and permanent deletion of the TRPV1-expressing C-fiber neuronal cell bodies in the dorsal root ganglia. resiniferatoxin transient receptor potential cation channel subfamily V member 1 Canis lupus familiaris