Title : A nonsteady-state agonist antagonist interaction model using plasma potassium concentrations to quantify the beta-2 selectivity of beta blockers.

Pub. Date : 1989 Apr

PMID : 2565392






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using pharmacokinetic-dynamic modeling in nonsteady-state conditions, of the antagonism by the beta blockers of the terbutaline-induced hypokalemia, the beta blocker beta-2 selectivity was quantitated in the terms of IC50 values representing plasma concentrations resulting in half-receptor occupancy. Terbutaline potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens