Title : Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas.

Pub. Date : 2015 May 15

PMID : 25646564






1 Functional Relationships(s)
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1 Using a combination of proteomics and small molecule intracellular metabolomics, we show herein that PtdOH acutely regulates the production of these pyrimidine metabolites through activation of CAD via mTOR signaling pathways independently of Akt. ptdoh AKT serine/threonine kinase 1 Homo sapiens