Title : Molecular mechanisms of human thyrocyte dysfunction induced by low concentrations of polychlorinated biphenyl 118 through the Akt/FoxO3a/NIS pathway.

Pub. Date : 2015 Sep

PMID : 25644787






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In addition, mRNA and protein levels of Akt were increased significantly in the PCB118-treated groups, whereas FoxO3a expression did not show particular variation. 2,3',4,4',5-pentachlorobiphenyl AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, exposure to PCB118 was associated with a significant increase of the protein levels of p-Akt and p-FoxO3a, and these effects were blocked by LY294002. 2,3',4,4',5-pentachlorobiphenyl AKT serine/threonine kinase 1 Homo sapiens
3 Our research suggests that PCB118 may induce thyrocyte dysfunction through the Akt/FoxO3a/NIS signalling pathway, which provides potential new insights for finding interventions to counteract the damage to the human body caused by PCBs. 2,3',4,4',5-pentachlorobiphenyl AKT serine/threonine kinase 1 Homo sapiens