Title : Rational design of selenadiazole derivatives to antagonize hyperglycemia-induced drug resistance in cancer cells.

Pub. Date : 2015 Mar

PMID : 25641920






1 Functional Relationships(s)
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1 However, the synthetic selenadiazole derivatives effectively potentiated the cellular uptake of DOX and enhanced the antiproliferative activity of DOX on HepG2 cells by induction of apoptosis, via regulation of ROS-mediated AMPK activation, inhibition of mTORC1, and an increase in DNA damage. Doxorubicin CREB regulated transcription coactivator 1 Mus musculus