Title : Metformin down-regulates endometrial carcinoma cell secretion of IGF-1 and expression of IGF-1R.

Pub. Date : 2015

PMID : 25640355






3 Functional Relationships(s)
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1 Metformin down-regulates endometrial carcinoma cell secretion of IGF-1 and expression of IGF-1R. Metformin insulin like growth factor 1 Homo sapiens
2 However, the IGF-1 level in the medium of cultured cells after treatment with metformin was decreased (p<0.05). Metformin insulin like growth factor 1 Homo sapiens
3 In summary, metformin can reduce the secretion of IGF-1 by Ishikawa and JEC EC cell lines and their expression of IGF-1R to deactivate downstream signaling involving the PI-3K/Akt pathway to inhibit endometrial carcinoma cell growth. Metformin insulin like growth factor 1 Homo sapiens