Title : Guanosine 3':5'cyclic monophosphate and activators of guanylate cyclase inhibit secretagogue-induced corticotropin release by rat anterior pituitary cells.

Pub. Date : 1989 Feb 15

PMID : 2563941






2 Functional Relationships(s)
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1 The hormonal response to corticotropin-releasing factor (10(-10) mol/l), vasopressin (10(-9) mol/l) as well as KC1 (48 mmol/l) was reduced by membrane permeant analogs of cGMP, such as 8-BrcGMP and dibutyryl-cGMP. 8-bromoguanosino-3',5'-cyclic monophosphorothioate arginine vasopressin Rattus norvegicus
2 The 8-BrcGMP analog (10(-5) mol/l) inhibited corticotropin release in response to corticotropin-releasing factor by 30%, that to vasopressin by 70%, and that to KCl by 50%. 8-bromoguanosino-3',5'-cyclic monophosphorothioate arginine vasopressin Rattus norvegicus