Pub. Date : 2015 May
PMID : 25631176
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of NFATc1 in prostate cancer progression: cyclosporine A and tacrolimus inhibit cell proliferation, migration, and invasion. | Tacrolimus | nuclear factor of activated T cells 1 | Homo sapiens |
| 2 | In prostate cancer cell lines, CsA and FK506 inhibited NFATc1 expression and its nuclear translocation, NFAT transcriptional activity, and the expression of c-myc, a downstream target of NFAT. | Tacrolimus | nuclear factor of activated T cells 1 | Homo sapiens |
| 3 | Thus, NFATc1 inactivation, especially using CsA and FK506, has the potential of being a therapeutic approach for not only hormone-naive but also castration-resistant prostate cancers. | Tacrolimus | nuclear factor of activated T cells 1 | Homo sapiens |