Title : Three steps to breaking immune tolerance to lymphoma: a microparticle approach.

Pub. Date : 2015 Apr

PMID : 25627654






1 Functional Relationships(s)
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1 Because of the vesicant activity of doxorubicin, microparticles made of biodegradable polymer poly(lactide-co-glycolide) or PLGA can safely deliver doxorubicin intratumorally and are effective vaccine adjuvants, (ii) enhancing T-cell activation using anti-OX40 and (iii) sustaining T-cell responses by checkpoint blockade using anti-CTLA-4. Polymers cytotoxic T-lymphocyte associated protein 4 Homo sapiens